What interferes with glucometer readings?
If you live with a condition that causes recurring low blood sugar, such as congenital hyperinsulinism, a metabolic disorder, or even diabetes, chances are the glucometer is already one of your best friends. It’s a great device, right? With just a tiny drop of blood, it tells you whether your glucose levels are okay or if you need to take action.
But here’s the important part: although glucometers are super useful tools, they’re not perfect. There are plenty of things that can interfere with their readings and give you numbers that don’t accurately reflect what’s happening in your body. And when it comes to hypoglycemia, that lack of accuracy can be a big problem.

Interferences in glucometer readings can come from many different sources.
On one hand, there are environmental factors such as temperature, humidity, or even altitude. Yes, the weather can play a much bigger role than you might imagine.
On the other hand, there are human errors. Because let’s be honest: we don’t always use the test strips as carefully as we should, and sometimes we even test without properly washing our hands…
And finally, there’s our own body, with things like certain medications (e.g., acetaminophen, maltose, galactose, icodextrin) we take, or hematocrit levels —very low or very high hematocrit values (anemia, dehydration, etc.)— which can also influence the readings.
All of this can cause your glucometer to show a number that looks like everything is fine when it really isn’t, or vice versa.
Think of it this way: the glucometer is like that friend who gives you advice. They’re usually right, but not infallible. That’s why it’s so important to understand how these interferences work and what you can do to avoid them.
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The role of the environment: when the weather gets in the way
We don’t often think about it, but the weather can have a huge impact on how your glucometer works. Extreme temperatures, for example, can be a real headache.
If it’s very hot, the chemical reactions in the test strips speed up, which can make your glucose levels look higher than they really are. On the other hand, cold can slow down those same reactions and give you a lower reading. And humidity? Well, it can damage the strips and make things even more complicated.
Did you know that even altitude can affect readings? In high places, where there’s less oxygen, the enzymatic reactions in the strips can change. This can cause the glucometer to underestimate your glucose levels. So if you’re in the mountains and the number you see doesn’t match how you feel, now you know what might be happening…
To manage this, it’s always a good idea to store your glucometer and test strips in a cool, dry place. If you’re in a location with extreme temperatures or high humidity, try to run the test in a more controlled environment. And if you live at high altitudes or plan to travel to such places, consider getting a glucometer designed to handle those conditions.
Human errors: because we’re human, after all
Now let’s talk about us, humans. Even if we don’t do it on purpose, it’s easy to make mistakes when using the glucometer. One of the most common is mishandling the test strips. For example, touching the area where the blood is applied can contaminate it with oils, lotions, or dirt from your hands, which can affect the result.
And please, let’s not forget that those strips have an expiration date. Using expired strips is like trying to listen to music with broken headphones—it just won’t work well.
The size and purity of the blood sample are also crucial. If you use a drop that’s too small or if the blood is contaminated with sweat, lotion, or anything else, the readings can be completely wrong. Here’s a tip: if the first drop of blood doesn’t look clean, you can wipe it away and use the second one for the test.
The most important thing here is to be careful. Wash your hands well with soap and water before testing. Make sure they’re completely dry. And handle the test strips as if they were pieces of glass: carefully, and only by the edges.
What happens if you trust an incorrect reading?
When it comes to hypoglycemia, every reading counts. Imagine your glucometer says everything is fine, but in reality, your glucose levels are very low. This can be dangerous, because untreated hypoglycemia can lead to serious symptoms such as dizziness, confusion, fainting, and even more severe emergencies.
That’s why it’s always important to listen to your body. If you feel something isn’t right but the glucometer says otherwise, trust your intuition. Repeat the test or check with your doctor to be sure.
The glucometer is a tool, not an oracle
The glucometer is a great tool, but it’s not perfect. It’s like a co-pilot in the car: it helps you navigate, but the final decision is yours. Using it correctly, understanding its limitations, and working together with your doctor can make a real difference in managing hypoglycemia.
At The Hippo House, we know how important it is to understand how these things work. That’s why, in addition to useful information like this, we also offer educational resources and fun activities so that both children and adults can learn more about hypoglycemia. Our goal is for families to feel safer and more prepared to handle any situation.
If you’re looking for a place to learn and share experiences, welcome to Hippo!
If your readings don’t match how you feel, check with your medical team. Never ignore hypoglycemia symptoms, even if the glucometer shows normal.
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As you can see, we have lots of ideas, dreams, and good intentions. If you give us a hand, we’ll be able to do sooooo many more things for and with children who suffer from hypoglycemia. Millions of thanks!